How native speakers pronounce “drug”

having high cholesterol isn't the best thing, and so the doctor says, "You know, I'd like to give you a drug that will help you lower your cholesterol, a statin."

Inside the mind of a master procrastinator — Tim Urban · TED

Now, what is this, the NNT? It's the number of people that need to take a drug or undergo a surgery or any medical procedure

Inside the mind of a master procrastinator — Tim Urban · TED

I ran through the numbers myself. 300 people have to take the drug for a year before one heart attack, stroke or other adverse event is prevented.

Inside the mind of a master procrastinator — Tim Urban · TED

and that is, "Tell me about the side effects." Right? So for this particular drug, the side effects occur in five percent of the patients.

Inside the mind of a master procrastinator — Tim Urban · TED

not very likely it's going to happen to me, I'll still take the drug." But wait a minute.

Inside the mind of a master procrastinator — Tim Urban · TED

so you don't have to manufacture the chain of reasoning on the spot. 300 people take the drug, right? One person's helped, five percent of those 300 have side effects,

Inside the mind of a master procrastinator — Tim Urban · TED

that's 15 people. You're 15 times more likely to be harmed by the drug than you are to be helped by the drug.

Inside the mind of a master procrastinator — Tim Urban · TED

You're 15 times more likely to be harmed by the drug than you are to be helped by the drug. Now, I'm not saying whether you should take the statin or not.

Inside the mind of a master procrastinator — Tim Urban · TED

that high that people tend to seek out when they use cannabis recreationally. And when you're pulled over for those roadside drug tests, it's the THC that they're looking for.

Can Cannabis Help You Sleep? Here’s the Science | Jen Walsh | TED · TED

or that relaxed post-exercise feeling. Don't worry, these ones are not being detected by those roadside drug tests, so you can continue with your marathon training.

Can Cannabis Help You Sleep? Here’s the Science | Jen Walsh | TED · TED

Joe and John have been best friends for many decades. When Joe was struggling with alcohol and drug use, John got him into recovery.

Why Friendship Can Be Just As Meaningful as Romantic Love | Rhaina Cohen | TED · TED

Now, you might be likely to invest if that product was a drug or a device, but what if that product was a park?

What makes us get sick? Look upstream | Rishi Manchanda

I didn't have 15 years and a billion dollars to develop a new drug from scratch. The good news is that those seven chemotherapies that had saved my life,

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

So I thought to myself, "Maybe there's another drug, made for another disease that could also be repurposed for me."

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

or mechanisms in the body, and can therefore be treated with the same drug. And amazingly, doctors can prescribe any FDA-approved drug

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

and can therefore be treated with the same drug. And amazingly, doctors can prescribe any FDA-approved drug for any disease where they believe the benefit outweighs the risk,

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

So I began to study my own blood in the lab to try to find a repurposed drug for me. I discovered that a communication line in my immune system

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

was turned into overdrive, and that a decades-old transplant drug might be able to turn it off. It had never been used before for my disease,

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

a nonprofit organization that's on a mission to unlock the full potential of each and every drug to treat each and every disease that it possibly can.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

Like Kylo, who began her freshman year of nursing school after we repurposed a bone-marrow cancer drug to save her life, which is now being studied in clinical trials.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

And Michael, who walked his son down the aisle on his wedding day, after we repurposed a melanoma drug to treat his rare cancer, which is now being used all over the world for that rare cancer.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

could treat many more of these diseases, and for less than one percent of the cost of new drug development, and way faster.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

And then, we use artificial intelligence to look across the millions of drug-disease matches to identify the best opportunities to reduce suffering

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

but we're already helping patients. The very first time we used a high-scoring drug from our algorithm was for a patient with Castleman disease, the disease that I have.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

because he was getting ready to be transferred to hospice care. But we recommended this number-one drug from our platform, and amazingly, it saved his life.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

Like, you're telling me that there are dying people waiting for a drug to be discovered, but actually, they can just go down to their corner pharmacy,

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

And in fact, companies will oftentimes consider 15, 20 or even 30 diseases for a given drug, but they have to pick the one or two to focus on.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

is that we really want you guys to all be a part of the solution. So if you've ever received a drug that was repurposed for your disease, received a drug off-label, tell us about it.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

So if you've ever received a drug that was repurposed for your disease, received a drug off-label, tell us about it. Go to everycure.org/ideas.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

If you know the druggable targets, then the drug industry can begin to work on things. I have another company I'm associated with

The AI Revolution Is Underhyped | Eric Schmidt | TED · TED

by doubling down on the things he wanted for me. I chased academic honors like a drug. I played not one, but two Division I college sports.

Lessons from My Father’s Final Days | Laurel Braitman | TED · TED

We use an AI platform to scan across the world's knowledge of every drug and every disease to find out new uses for the medicines that we already have.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

beginning to receive chemotherapy and then discovering a drug that wasn't made for my disease that could save my life.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

that could save my life. A drug that was made for organ transplant rejection, I thought could maybe treat my disease.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

And it's been 11.5 years that I've been in remission on this medicine. I mean, the moment that this drug started saving my life, all I've been able to think about is how many more drugs are out there

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

but they're saving my life. Maybe there's another drug made for another disease. It was just that simple of a concept: these things work,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

And the other was just the realization that I had no other option. I didn't have a billion and 15 years to create a brand new drug. If I wanted to survive, I would have to find something that existed.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

DF: Yeah, there are many cases where we aren't able to find a repurposed drug for a patient and they do pass away from their disease.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

I guess I'd say hyperlocal with me in the sense that I was very sick and found a drug that I repurposed for myself, and then immediately, like you, started thinking,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

and then immediately, like you, started thinking, OK, if this drug worked for me, are there other drugs that could work for other patients?

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

But then when you think about what artificial intelligence can do to scan across the world's knowledge of every drug and every disease -- CD: Quickly.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

because there's 4,000 drugs and there's 18,000 diseases. So if you tried every drug for every disease, it would be 75 million possibilities.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

that we, humans, have already done. You know, we've studied this drug in the lab for this disease, and it maybe showed promise,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

and it maybe showed promise, but then we moved on to that drug for that disease because this wasn't a profitable opportunity.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

But then for us humans to say this drug, for this disease really needs to be studied in the lab, this one needs to be in clinical trials,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

that I shared in the spring, it was a drug called leucovorin. It was developed for patients on a form of chemotherapy decades ago,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

to prevent a vitamin from getting in their brain. But if you give them this old drug that was developed to be given to patients on chemotherapy,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

brilliant work was done, but the last mile wasn't taken. And that's because it's a cheap old drug, and it's not that anyone wants to suppress the information,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

it's just that no one's incentivized to get the word out. There's no drug company behind this. And so these are the kinds of systems problems that exist that you see,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

to make sure that you've got an awesome team. For me, I know a lot about drug repurposing and a lot about immunology, and I can match drugs to diseases,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

That's like literally showing patients that are here because of a repurposed drug and also those who are waiting for a drug. And I think that being able to really visualize,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

Antibiotics affect the entire microbiome and their overuse can lead to drug resistance. Diet and probiotics are nonspecific

CRISPR's Next Advance Is Bigger Than You Think | Jennifer Doudna | TED · TED

Now, if that seems contradictory to you, I suggest that you flip through the pages of any pharmaceutical drug catalog from the early 20th century. I mean, these things are just a laundry list of deadly poisons,

Steven Johnson: How humanity doubled life expectancy in a century | TED · TED

a cure for strep throat actually, targeted at children. At the time, there was a new drug called sulfa drugs that were kind of a forerunner of antibiotics.

Steven Johnson: How humanity doubled life expectancy in a century | TED · TED

So a chemist at this startup came up with the brilliant idea of dissolving the sulfa drug in diethylene glycol

Steven Johnson: How humanity doubled life expectancy in a century | TED · TED

which is what is needed for biologists to use it, and for drug design and for disease understanding, which is what AlphaFold unlocks.

How AI Is Unlocking the Secrets of Nature and the Universe | Demis Hassabis | TED · TED

which part of the surface of the protein you're going to target with your drug compound. And Isomorphic is extending this work we did in AlphaFold

How AI Is Unlocking the Secrets of Nature and the Universe | Demis Hassabis | TED · TED

in the coming few years. DH: I think we'll be able to get down drug discovery from years to maybe months.

How AI Is Unlocking the Secrets of Nature and the Universe | Demis Hassabis | TED · TED

This is a false claim that airplane vapor trails are actually a deliberate attempt to drug populations or control the weather with chemicals.

Why Does Uncertainty Bother Us So Much? | Adam Kucharski | TED · TED