How native speakers pronounce “drugs”

And you've probably heard of statins, you know that they're among the most widely prescribed drugs in the world today,

Inside the mind of a master procrastinator — Tim Urban · TED

But GlaxoSmithKline estimates that 90 percent of the drugs work in only 30 to 50 percent of the people. So the number needed to treat for the most widely prescribed statin,

Inside the mind of a master procrastinator — Tim Urban · TED

Did you know that one of the first fertility drugs was made from the pee of Catholic nuns,

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But as I consider myself to be a generally good sleeper, and also because I know how these drugs work, I didn’t want this.

Why Daylight Is the Secret to Great Sleep | Christine Blume | TED · TED

With every one of these discoveries, all I can think about is how many more life-saving drugs are sitting at our local pharmacies

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

that could be life-saving for patients with diseases today. Because see, us humans, we've developed 4,000 drugs for about 4,000 diseases, but there are over 14,000 diseases that don't have a single approved therapy.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

and many more of us will develop diseases with limited treatment options. We know that many of these FDA-approved drugs could treat many more of these diseases,

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

and way faster. So why aren't we repurposing drugs? Well, the short answer is that it's just not profitable to pursue a new use

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

especially for a rare disease, and the 80 percent of drugs that are already generic, it just costs too much to do the clinical trials,

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

and companies can't expect to make back the costs in sales. Instead, we focus on new drugs for profitable diseases, and no one, not the NIH, not the FDA, not pharma,

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

We're utilizing artificial intelligence to scan across the world's knowledge of all 4,000 drugs and all 18,000 diseases to find the most promising opportunities to save and improve lives.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

Well, we do something similar, but instead, we use the world's knowledge of all approved drugs and all diseases and the connectedness between them

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

and the connectedness between them to predict which drugs might be useful in new ways, much faster than any team of humans ever could.

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

because his doctor had tried everything that he thought was possible. We recommended three drugs that are commonly used for multiple myeloma,

How Nearly Dying Helped Me Discover My Own Cure (and Many More) | David Fajgenbaum | TED · TED

As you know, those are the things that ultimately drive the cost structure of drugs. That's an example.

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mind just for the Afghans themselves but also exporting drugs and instability and all the like that that is what we are

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David Fajgenbaum: I’m on a mission to save and improve lives with the drugs that we already have. We use an AI platform to scan across the world's knowledge

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

I mean, the moment that this drug started saving my life, all I've been able to think about is how many more drugs are out there that are made for one disease that could actually save way more lives.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

DF: Well, there's a couple of things. One was that I'd been getting seven different chemotherapy drugs with each of my relapses.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

And I kept thinking, everyone's telling me there's no drugs for Castleman's, but you keep giving me chemotherapy and they don't work long-term,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

So it was the constraints of the system. And then what's been so crazy is how many drugs there are out there that can help more people that we've been neglecting for so long.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

that can help more people that we've been neglecting for so long. CD: And so much funding has gone into developing those drugs, too. It's like, you already have all this R and D,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

And for us similarly, we have a very bold and broad mission. And that's to save and improve lives with the drugs we already have by repurposing medicines.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

And I was able to get in touch with his doctor on that Saturday and recommend three drugs that were made for multiple myeloma, which is a cancer that's similar to POEMS syndrome,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

which is a cancer that's similar to POEMS syndrome, but those drugs are not used for POEMS. And the doctor and I had a long discussion

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

he's been in remission. These drugs were always there. They were just made for a different disease,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

OK, if this drug worked for me, are there other drugs that could work for other patients? And at first it was just Castleman's patients,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

other rare diseases. We've now repurposed 14 drugs for diseases they weren't intended for. And now thousands of patients are alive because of these drugs

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

We've now repurposed 14 drugs for diseases they weren't intended for. And now thousands of patients are alive because of these drugs that weren't made for their disease.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

and I'm very proud of our team, we can study, you know, a couple drugs for a couple diseases a year and make a lot of progress, and we were really proud of that.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

DF: Almost instantly, right? To come up with predictions on how likely drugs are to work in new diseases, it's really mind boggling.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

it took us 100 days to compute 75 million scores, because there's 4,000 drugs and there's 18,000 diseases. So if you tried every drug for every disease,

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

The scores are really accurate, they're telling us that drugs like lidocaine can help potential patients with breast cancer.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

there's got to be some entity that's responsible for making sure the drugs we have work for all the patients that can benefit. And the more I looked, the more I learned that there wasn't this system.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

For me, I know a lot about drug repurposing and a lot about immunology, and I can match drugs to diseases, but I really don't have strengths in systems and policy.

How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections · TED

finding sources of diseases, predicting your reaction to drugs, and guiding treatment options based on your own DNA.

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And we're already seeing many of these benefits land in our society from new antibiotics, new drugs, new materials. And this is the possible of AI.

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arsenic, mercury, belladonna, not to mention all the heroin and cocaine. A lot of medical historians believe that all-in pharmaceutical drugs were a net negative in terms of human health

Steven Johnson: How humanity doubled life expectancy in a century | TED · TED

a cure for strep throat actually, targeted at children. At the time, there was a new drug called sulfa drugs that were kind of a forerunner of antibiotics.

Steven Johnson: How humanity doubled life expectancy in a century | TED · TED

And for the first time, the FDA mandated the pharma companies show that their drugs were not harmful to consumers, which seems kind of obvious, but somebody had to figure that out.

Steven Johnson: How humanity doubled life expectancy in a century | TED · TED

which seems kind of obvious, but somebody had to figure that out. And so what we needed at that point was not just kind of new miracle drugs. We needed new institutions.

Steven Johnson: How humanity doubled life expectancy in a century | TED · TED

is that this is the beginnings of understanding disease and also maybe helpful for designing drugs. So if you know the shape of the protein,

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that allows us to do an incredible thing: to treat cancer without drugs or surgery, which we call radiotherapy.

The case for curiosity-driven research | Suzie Sheehy

just like taking care of your health -- you know, not smoking, not abusing alcohol or drugs, exercising regularly,

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Then there's general anesthesia. We know what combination of drugs will make a patient unconscious, but it's still not entirely clear exactly why they do.

Why Does Uncertainty Bother Us So Much? | Adam Kucharski | TED · TED